Effects of propranolol on marihuana-induced cognitive dysfunctioning
| Autor: | Glenn F. Kiplinger Ph.D., B A Marilyn Marx, William G. Drew, Loren L. Miller |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Adult
Male Injury control Accident prevention Trail Making Test Statistics as Topic Poison control Administration Oral Propranolol Placebo Cognition Memory Task Performance and Analysis Medicine Humans Pharmacology (medical) Drug Interactions Dronabinol Cannabis Pharmacology Clinical Trials as Topic Psychological Tests business.industry Adrenergic blocking Smoking medicine.disease Anesthesia Medical emergency business medicine.drug |
| Zdroj: | Clinical pharmacology and therapeutics. 13(4) |
| ISSN: | 0009-9236 |
| Popis: | Paid male volunteers were allowed to smoke marihuana cigarettes calibrated to deliver a dose of 25 µg per kilogram of delta-9-tetrahydrocannabinol (Δ-9-THC). All subjects were given propranolol or placebo (administered in a double-blind fashion), in 4 divided doses beginning 24 hours before and ending 2 hours prior to smoking. Marihuana smoking resulted in significant disruption in the recall of narrative material and moderate impairment in performance on a modified version of the Reitan Trail Making test. Stroop-Color Word performance was not affected by marihuana. Propranolol, a beta adrenergic blocking agent, failed to interact with marihuana to reduce its disruptive effects on any of the tests. |
| Databáze: | OpenAIRE |
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