INCREASED INTERLEUKIN-2 RECEPTOR AFFINITY IN NORMAL HLA A1 B8 DR3 SUBJECTS
| Autor: | M. Vindimian, G. Pomier, J. C. Le Petit, J. C. Healy |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male musculoskeletal diseases Interleukin 2 medicine.medical_specialty endocrine system diseases Lymphocyte medicine.medical_treatment Immunology Stimulation In Vitro Techniques Biology Lymphocyte Activation HLA-B8 Antigen law.invention HLA-DR3 Antigen HLA Antigens immune system diseases Cell surface receptor law Internal medicine Immunogenetics Genetics medicine Humans skin and connective tissue diseases Receptor HLA-A1 Antigen Lymphoblast Receptors Interleukin-2 Middle Aged medicine.anatomical_structure Cytokine Endocrinology Recombinant DNA Interleukin-2 Female medicine.drug |
| Zdroj: | European Journal of Immunogenetics. 17:371-377 |
| ISSN: | 1365-2370 0960-7420 |
| DOI: | 10.1111/j.1744-313x.1990.tb00888.x |
| Popis: | SUMMARY Twenty-two subjects (11 HLA A1 B8 DR3, 11 non-A1 B8 DR3) were tested for the capacity of their lymphocytes to express Tac molecules and interleukin-2 (IL-2) receptors (quantified using radiolabelled IL-2) after mitogen stimulation. Ten of these subjects (five Al B8 DR3 and five non-A1 B8 DR3) were also tested for the ability of their lymphocytes to proliferate under IL-2 stimulation. Al B8 DR3 subjects express a normal number of high-affinity IL-2 receptor sites, but the affinity of these receptors sites is significantly increased. Unexpectedly, Al B8 DR3 lymphoblasts show a lower response to IL-2 than non-Al B8 DR3 for high doses of recombinant IL-2. |
| Databáze: | OpenAIRE |
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