Extending expressed RNA genomics from surgical decision making for cytologically indeterminate thyroid nodules to targeting therapies for metastatic thyroid cancer

Autor: Syed Z. Ali, Paul W. Ladenson, Giulia C. Kennedy, Allan C. Golding, Richard T. Kloos, Allan Siperstein, Peter M. Sadow
Rok vydání: 2019
Předmět:
Thyroid nodules
Oncology
endocrine system
Cancer Research
medicine.medical_specialty
Biopsy
Fine-Needle

Clinical Decision-Making
Thyroid Gland
indeterminate cytology
030209 endocrinology & metabolism
Genomics
Malignancy
molecular diagnostics
Diagnosis
Differential

Machine Learning
Transcriptome
03 medical and health sciences
0302 clinical medicine
Internal medicine
Adenocarcinoma
Follicular

Biomarkers
Tumor

Humans
Medicine
RNA
Messenger

RNA
Neoplasm

RNA-Seq
Thyroid Neoplasms
Precision Medicine
business.industry
Thyroid
Molecular diagnostics
medicine.disease
Gene Expression Regulation
Neoplastic

medicine.anatomical_structure
Thyroid Cancer
Papillary

030220 oncology & carcinogenesis
thyroid nodule
Commentary
Thyroidectomy
Feasibility Studies
Reagent Kits
Diagnostic

Sample collection
business
Indeterminate
clinical validation
Zdroj: Cancer Cytopathology
ISSN: 1934-6638
1934-662X
Popis: The Afirma Genomic Sequencing Classifier (GSC) is a rule‐out test for malignancy/noninvasive follicular thyroid neoplasms with papillary‐like nuclear features among patients with Bethesda category III/IV nodules, whereas the complimentary Xpression Atlas provides genomic insights from a curated panel of 511 genes among GSC suspicious and Bethesda category V/VI nodules. Together, they facilitate personalized treatment decisions based on genomic insights derived from the transcriptome of the biopsied target and extend the diagnostic and therapeutic reach of cytopathologists and fine‐needle aspiration biopsy sample collection.
Databáze: OpenAIRE