Gene expression of transformed lens cells
| Autor: | M.W.A.C. Hukkelhoven, Hans Bloemendal, Ap A. Groeneveld, Johannes A. Lenstra, P.J.J.M. Weterings, R. A. M. M. Smits |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Hamster
Biology Mice Cellular and Molecular Neuroscience Crystallin Cricetinae Lens Crystalline Gene expression medicine Animals Cells Cultured Carcinogen Cell Transformation Viral Crystallins Molecular biology Sensory Systems In vitro Cell biology Ophthalmology Transformation (genetics) Cell Transformation Neoplastic medicine.anatomical_structure Gene Expression Regulation Cell culture Lens (anatomy) Cattle Electrophoresis Polyacrylamide Gel |
| Zdroj: | Experimental Eye Research. 35:549-554 |
| ISSN: | 0014-4835 |
| DOI: | 10.1016/s0014-4835(82)80069-9 |
| Popis: | In addition to our SV40-transformed hamster cell line (Bloemendal et al. 1980), two otherlenticular cell lines have been established. One was obtained by transformation of hamster lens cells with the carcinogen 3-methylcholanthrene, the other one by transformation of calf lens cells with SV40. The transformed cells revealed alterations in growth pattern and morphology, but only minor changes in gene expression. However, crystallin synthesis ceased in all cases. We hypothesize that elongation of the lens cells in vitro reflects a transition into fibroblast-like cells. |
| Databáze: | OpenAIRE |
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