Dual-modality probe for MRI and photoacoustic imaging: synthesis, and relaxometric characterization
| Autor: | Marie Devreux, Fabienne Dioury, Sophie Laurent, Céline Henoumont, Clotilde Ferroud |
|---|---|
| Přispěvatelé: | Université de Mons (UMons), Laboratoire de Chimie moléculaire, génie des procédés chimiques et énergétiques (CMGPCE), Conservatoire National des Arts et Métiers [CNAM] (CNAM) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Gadolinium-Chelate
Materials science Fluorophore [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging medical imaging Photoacoustic imaging in biomedicine photoacoustic pyclen molecular imaging 3. Good health Characterization (materials science) chemistry.chemical_compound ZW800-1 chemistry Medical imaging Dual probe Dual modality PCTA12 [CHIM.COOR]Chemical Sciences/Coordination chemistry Molecular imaging gadolinium bifunctional chelating agents multimodality Biomedical engineering MRI |
| Zdroj: | MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition International Conference on Multidisciplinary Sciences, 4th edition (MOL2NET 2018)-BIOCHEMPHYS-01: International Workshop on Med. Chem., Biotech., and Phys. Chem. International Conference on Multidisciplinary Sciences, 4th edition (MOL2NET 2018)-BIOCHEMPHYS-01: International Workshop on Med. Chem., Biotech., and Phys. Chem., 2018, Paris, France. pp.5865, ⟨10.3390/mol2net-04-05865⟩ |
| Popis: | International audience; Multimodality imaging based on complementary modalities is a way to improve the accuracy of medical diagnoses. For such purpose, multimodal probes combining the appropriate contrastophores into a single delivery are required. The project presented here deals with the combination of two modalities: magnetic resonance imaging (MRI), and photoacoustic imaging (PAI). The dual probe envisaged relies on a pyclen-based gadolinium(III) complex as contrast agent for MRI, together with ZW800-1 fluorophore for PAI, both of them being grafted on a linker derived from Llysine. The results presented here describe the synthetic pathway, and the relaxometric characterization of the dual compound. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|