Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk
| Autor: | Hideo Kunitoh, Ryusei Saito, Hiroshi Hirose, Kaoru Toyama, Noriko Yanagitani, Sachiyo Mimaki, Takashi Eguchi, Tokuki Sakiyama, Koichi Goto, Daizo Saito, Seiichiro Yamamoto, Tsutomu Ohta, Rumie Sasaki-Matsumura, Aya Kuchiba, Takashi Kohno, Tomotaka Sobue, Jun Yokota, Misao Ohki, Yutaka Nishiwaki |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Cancer Research Linkage disequilibrium Lung Neoplasms Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Reference Values Risk Factors Genotype medicine Humans SNP Carcinoma Small Cell Allele Lung cancer Aged Genetics Smoking Haplotype Exons General Medicine Odds ratio Middle Aged medicine.disease Phosphoric Monoester Hydrolases DNA Repair Enzymes Amino Acid Substitution Case-Control Studies Female |
| Zdroj: | Carcinogenesis. 27:2448-2454 |
| ISSN: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/bgl095 |
| Popis: | Fifty single-nucleotide polymorphisms (SNPs) associated with amino acid changes in 36 genes involved in diverse DNA repair pathways were assessed for associations with risk for small cell lung carcinoma (SCLC) by a case-control study consisting of 211 SCLC cases and 685 controls. An SNP, Val83Met, in the MTH1 (microtT homolog 1) gene encoding a triphosphatase that hydrolyzes pro-mutagenic oxidized nucleoside triphosphates, such as 8-hydroxy-dGTP and 2-hydroxy-dATP, showed the strongest and a significant association with SCLC risk [odds ratio (OR)=1.6, 95% confidence interval (CI): 1.2-2.2, P=0.004], while three other SNPs in the TP53, BLM and SNM1 genes, respectively, also showed marginal associations (0.05 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|