Micro RNA clusters in maternal plasma are associated with preterm birth and infant outcomes

Autor: Rajesh C. Miranda, Raymond P. Stowe, Joel C. Wommack, Jerome P. Trzeciakowski, R. Jeanne Ruiz
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Physiology
Maternal Health
lcsh:Medicine
Biochemistry
Labor and Delivery
Families
0302 clinical medicine
Pregnancy
Medicine and Health Sciences
Chromosomes
Human
Birth Weight
lcsh:Science
Children
Multidisciplinary
Obstetrics and Gynecology
Nucleic acids
Physiological Parameters
Premature birth
030220 oncology & carcinogenesis
Premature Birth
Gestation
Female
Infants
Research Article
Adult
Mothers
Locus (genetics)
Biology
Preterm Birth
Infant outcomes
03 medical and health sciences
Negatively associated
microRNA
Genetics
medicine
Humans
Non-coding RNA
Biology and life sciences
Body Weight
lcsh:R
Infant
Preeclampsia
medicine.disease
Human genetics
Gene regulation
Pregnancy Complications
MicroRNAs
030104 developmental biology
Gene Expression Regulation
Age Groups
People and Places
Birth
RNA
Women's Health
Population Groupings
lcsh:Q
Gene expression
Zdroj: PLoS ONE, Vol 13, Iss 6, p e0199029 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: The current study examined micro RNA (miRNAs) clusters from the maternal plasma to determine their association with preterm birth (PTB) and infant birth outcomes. A subsample of 42 participants who spontaneously delivered either preterm (≤37 weeks) or term was selected from a parent sample of 515 pregnant Mexican American women. Plasma samples and prenatal data were collected at a single mid-gestation time point (22–24 weeks’ gestation) and birth outcomes were obtained from medical records after delivery. Circulating miRNAs were analyzed by qPCR. When miRNAs were grouped according to chromosomal cluster rather than expression level, individual miRNAs correlated strongly with other individual miRNAs within their respective genomic locus. miRNAs from the c19mc cluster negatively correlated with c14mc miRNAs, and this relationship was more pronounced in PTB. Clusters c14mc was negatively associated with length of gestation; while the c19mc was positively associated with length of gestation and infant head circumference. Together, these findings suggest that groups of miRNAs from common chromosomal clusters, rather than individual miRNAs, operate as co-regulated groups of signaling molecules to coordinate length of gestation and infant outcomes. From this evidence, differences in cluster-wide expression of miRNAs are involved in spontaneous PTB.
Databáze: OpenAIRE
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