Copper-catalyzed C2-selective alkynylation of chromones via 1,4-conjugate addition

Autor:	Yan-Wu Li, Jie Lei, Zhong-Zhu Chen, Meng-Lan Lv
Rok vydání:	2023
Předmět:	Inorganic Chemistry Organic Chemistry Drug Discovery General Medicine Physical and Theoretical Chemistry Molecular Biology Catalysis Information Systems
DOI:	10.21203/rs.3.rs-2453624/v1
Popis:	Copper-catalyzed selective alkynylation with N-propargyl carboxamides as nucleophiles has been successfully developed for the synthesis of C2-functionalized chromanones. Under optimized reaction conditions, 21 examples were obtained in one-pot procedure through 1,4-conjugate addition. This protocol features readily available feedstocks, easy operations and moderate to good yields, which provides viable access to pharmacologically active C2-functionalized chromanones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1256393f4d6ace55253d566eda872bbc https://doi.org/10.21203/rs.3.rs-2453624/v1 Zobrazit plný text záznamu