Epidemiology of Huntington’s Disease in Rijeka District, Yugoslavia

Autor:	Licia Antonelli, Dubravka Šepić-Grahovac, Eris Materljari, Juraj Sepčić
Rok vydání:	1989
Předmět:	Adult Male huntington's disease epidemiology medicine.medical_specialty Epidemiologic study Epidemiology business.industry Yugoslavia Disease medicine.disease Diagnosis Differential Huntington Disease Huntington's disease Humans Medicine Female Neurology (clinical) business Psychiatry
Zdroj:	Neuroepidemiology. 8:105-108
ISSN:	1423-0208 0251-5350
DOI:	10.1159/000110172
Popis:	Epidemiologic study of Huntington's disease (HD) in the Rijeka district represents the first research of its kind carried out in Yugoslavia. After a detailed investigation of all available sources of health information, ten families, with a total number of 24 HD patients, were found. The prevalence rate of HD on March 31, 1981, was 4.46/100,000 population. Most of the patients involved were members from the second or third familial generation. The age at recognition of disease was 41.6 years, with earlier onset among the males. Involuntary movements frequently appeared as the initial symptomatology (45.8%). Duration of the disease from initial symptomatology to death averaged at 10.6 years. Six of nine patients who died had committed suicide. It took physicians of primary care, neurologists, and psychiatrists 5.3 years (1-12 years) to make a definite diagnosis. Nine of the affected families from Rijeka district were autochthonic households. Six of these families immigrated from Saxony, Slovakia and Upper Carinthia during the reign of the Habsburg dynasty (1619-1780).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1255f819d65abb23997d980727d1c51b https://doi.org/10.1159/000110172 Zobrazit plný text záznamu