Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes

Autor:	Liu-Yi Liu, Tian-Zhu Ma, You-Liang Zeng, Wenting Liu, Zong-Wan Mao
Rok vydání:	2022
Předmět:	G-Quadruplexes Colloid and Surface Chemistry Aminoquinolines Humans Neurodegenerative Diseases General Chemistry DNA Ligands Picolinic Acids Biochemistry Amides Catalysis
Zdroj:	Journal of the American Chemical Society. 144(26)
ISSN:	1520-5126
Popis:	The nucleic acid G-quadruplex (G4) has emerged as a promising therapeutic target for a variety of diseases such as cancer and neurodegenerative disease. Among small-molecule G4-binders, pyridostatin (PDS) and its derivatives (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12559dfd04976beb34c95e55583894d8 https://pubmed.ncbi.nlm.nih.gov/35749293 Zobrazit plný text záznamu