Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes
Autor: | Liu-Yi Liu, Tian-Zhu Ma, You-Liang Zeng, Wenting Liu, Zong-Wan Mao |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Journal of the American Chemical Society. 144(26) |
ISSN: | 1520-5126 |
Popis: | The nucleic acid G-quadruplex (G4) has emerged as a promising therapeutic target for a variety of diseases such as cancer and neurodegenerative disease. Among small-molecule G4-binders, pyridostatin (PDS) and its derivatives ( |
Databáze: | OpenAIRE |
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