Distribution of rotavirus genotypes in three Croatian regions among children ≤5 years of age (2012-2014)
| Autor: | Vjekoslav Krželj, Marija Tonkić, Maja Vrdoljak, Iva Butić, Marija Hegeduš Jungvirth, Vladimir Trkulja, Marina Payerl Pal, Goran Tešović, Marija Gužvinec, Ivo Ivić |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Croatia / epidemiology
0301 basic medicine Male Rotavirus acute gastroenteritis children diarrhea genotypes rotavirus Distribution (economics) medicine.disease_cause Diarrhea / virology Feces 0302 clinical medicine Gastroenteritis / virology Genotype Prevalence 030212 general & internal medicine Prospective Studies Child Rotavirus / isolation & purification Gastroenteritis / epidemiology General Medicine Rotavirus vaccine Hospitals Gastroenteritis Diarrhea Infectious Diseases Child Preschool Rotavirus Infections / prevention & control Rotavirus / immunology language Female medicine.symptom Microbiology (medical) Croatia 030106 microbiology Biology Rotavirus Infections lcsh:Infectious and parasitic diseases 03 medical and health sciences Diarrhea / epidemiology medicine Humans Gastroenteritis / prevention & control lcsh:RC109-216 Rotavirus Vaccines / immunology Genotyping Diarrhea / prevention & control Rotavirus / genetics Croatian business.industry Immunization Programs Infant Newborn Rotavirus Vaccines Infant Virology language.human_language Feces / virology Immunization Rotavirus Infections / virology Rotavirus Infections / epidemiology business |
| Zdroj: | International Journal of Infectious Diseases, Vol 89, Iss, Pp 3-9 (2019) |
| ISSN: | 1878-3511 |
| Popis: | Objectives: Rotavirus is the major cause of severe diarrhea in young children worldwide. In countries like Croatia, where rotavirus vaccine has not been introduced in the national immunization program, prospective surveillance is necessary to establish the diversity of rotavirus strains. The aim of this study was to describe the prevalence and geographical distribution of rotavirus strains in Croatia and to detect the possible emergence of novel strains. Methods: The study was conducted among children ≤5 years of age with acute gastroenteritis at three hospitals located in different geographical regions of Croatia, during the years 2012 to 2014. Rotavirus was detected in stools using an immunochromatographic assay and then sent for further molecular analysis. Results: Genotyping of 822 rotaviruses showed that the predominant circulating strain was G1P[8] (61.9%), followed by G2P[4] (19.5%), G1P[4] (3.9%), and G3P[8] (2.9%). A high prevalence of reassortants among common human rotavirus genotypes was detected (7.7%). Possible zoonotic reassortants were found, including G8 and G6 strains. The latter is described for the first time in Croatia. Conclusions: This study represents pre-vaccination data that are important for decisions regarding immunization strategies in Croatia. The high prevalence of ‘common’ rotavirus strains circulating in Croatia may advocate for rotavirus vaccine introduction, but further surveillance is necessary to monitor the possible emergence of novel genotypes. Keywords: Rotavirus, Diarrhea, Acute gastroenteritis, Children, Genotypes |
| Databáze: | OpenAIRE |
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