Serum cystatin C as an indicator for early detection of diabetic nephropathy in type 2 diabetes mellitus
| Autor: | Ayman El Badawy, Mohamed Shawky El-Sayed, Abdelmon'em Ahmed, Amr Mohamed, Rasha Salah Omar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Renal function 030209 endocrinology & metabolism urologic and male genital diseases Nephropathy Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine medicine Humans Outpatient clinic Diabetic Nephropathies Prospective Studies 030212 general & internal medicine Cystatin C Aged biology business.industry Type 2 Diabetes Mellitus General Medicine Middle Aged Prognosis medicine.disease Cross-Sectional Studies Early Diagnosis Diabetes Mellitus Type 2 biology.protein Albuminuria Female medicine.symptom business Biomarkers Follow-Up Studies Glomerular Filtration Rate |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 13:374-381 |
| ISSN: | 1871-4021 |
| Popis: | Background Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. The metabolic dysregulations associated with DM causes secondary pathophysiological changes in multiple organ systems which result in various complications, responsible for the morbidity and mortality associated with the disease. Methods The present study was carried out on 40 patients with type 2 diabetes mellitus, who were recruited from those attending outpatient clinic and inpatient of Internal Medicine Department at The National Institute of Diabetes and Endocrinology from January 2017 to june 2017. Results The mean Cystatin C values in Group I were 0.74, group II were 1.07. and in Group III were 3.25, The results show that the Cystatin C values were raised even in the patients with Normoalbuminuria with GFR ≥90 whom clinical albuminuria had not yet started. Conclusions serum Cystatin C may be considered as an early marker, than microalbuminuria and serum creatinine, the commonly used marker for nephropathy, for declining renal function, in diabetic subjects. Further studies in larger population are needed to confirm this result. |
| Databáze: | OpenAIRE |
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