Myxoid Variant of Epithelioid Leiomyosarcoma of the Uterus
| Autor: | Eisei Ishikawa, Eiko Takeuchi, Toshihito Shinagawa, Kaoru Saito, Masanori Iwata, Yoshio Aida, Mamoru Tadokoro |
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| Rok vydání: | 2008 |
| Předmět: |
Leiomyosarcoma
Pathology medicine.medical_specialty Uterine sarcoma Uterus Vimentin General Medicine Anatomy Biology medicine.disease Immunohistochemistry Pathology and Forensic Medicine Microscopy Electron medicine.anatomical_structure Uterine Neoplasms medicine biology.protein Humans Female Desmin Enlarged Uterus Uterine cavity Uterine Neoplasm Aged |
| Zdroj: | Pathology International. 41:778-783 |
| ISSN: | 1320-5463 |
| DOI: | 10.1111/j.1440-1827.1991.tb03351.x |
| Popis: | A rare case of myxoid variant of epithelioid leiomyosarcoma of the uterus in a 76-year-old woman is reported. Palpation and computed tomography revealed an enlarged uterus. Total hysterectomy and bilateral salpingo-oophorectomy were performed, and a hemispheric tumor, measuring 2.7 x 2.5 x 1.8 cm, was found protruding into the uterine cavity of the upper uterine segment. The tumor contained a prominent myxoid stroma and epithelioid tumor cells, which were round and polygonal in shape and showed positive immunoreactivity for desmin and vimentin. High mitotic activity was observed in the tumor cells. Electron microscopic examination revealed bundles of filaments in the cytoplasm and fine reticular material in the extracellular matrix. Histochemically, the myxoid stroma contained abundant acid mucopolysaccharide. The tumor cells were considered to originate from smooth muscle cells, while the myxoid stroma expressed varying differentiation of uterine mesenchymal cells. The patient is currently well with no evidence of recurrence or metastasis one year after the operation. |
| Databáze: | OpenAIRE |
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