Survival in patients with submandibular gland carcinoma — Results of a multi-institutional retrospective study

Autor: Kazuyuki Ichimaru, Ryo Asato, Ichiro Tateya, Koichi Omori, Keigo Honda, Hisanobu Tamaki, Shinzo Tanaka, Koichiro Yamada, Yoshiharu Kitani, Masanobu Mizuta, Koji Ushiro, Shinji Takebayashi, Tsuyoshi Kojima, Toshiki Maetani, Yohei Kumabe, Shogo Shinohara, Morimasa Kitamura
Rok vydání: 2018
Předmět:
Adult
Male
Oncology
medicine.medical_specialty
Multivariate analysis
Disease
Adenocarcinoma
Disease-Free Survival
Myoepithelioma
Submandibular Gland Carcinoma
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
In patient
030223 otorhinolaryngology
Lymph node
Aged
Neoplasm Staging
T classification
Aged
80 and over
Univariate analysis
business.industry
Carcinoma
Retrospective cohort study
General Medicine
Middle Aged
Prognosis
Carcinoma
Adenoid Cystic
Submandibular Gland Neoplasms
Survival Rate
medicine.anatomical_structure
Otorhinolaryngology
Lymphatic Metastasis
030220 oncology & carcinogenesis
Multivariate Analysis
Carcinoma
Squamous Cell
Carcinoma
Mucoepidermoid
Female
Radiotherapy
Adjuvant
Surgery
Lymph Nodes
Neoplasm Grading
Neoplasm Recurrence
Local
business
Zdroj: Auris Nasus Larynx. 45:1066-1072
ISSN: 0385-8146
DOI: 10.1016/j.anl.2018.01.011
Popis: Objective Clinical studies demonstrating the prognostic factors in submandibular gland carcinoma are limited because the tumor is relatively rare. The aim of this study was to identify clinical outcomes and prognostic factors in submandibular gland carcinoma. Methods The study included 65 patients with submandibular gland carcinoma who underwent initial surgical treatment at the Kyoto University and its affiliated hospitals. Results The 3-year overall survival (OS), disease specific survival, locoregional control (LRC), and no distant metastasis (NDM) rates were 74.2%, 74.2%, 90.0%, and 64.8%, respectively. In the current follow-up study, 16 patients died of the disease, 5 patients were alive with recurrence, 43 patients were alive without disease, and 1 patient died of unrelated disease without recurrence. All patients who died of the disease had developed distant metastasis. Based on univariate analysis, tumor grade (high grade) and lymph node metastases (≥N2) were significant prognostic factors for OS and LRC. It also revealed tumor grade (high grade), T classification (≥T3), and lymph node metastases (≥N2) were significant for distant metastasis. Multivariate analysis showed the following significant prognostic factors: lymph node metastases (≥N2) for OS, LRC, and NDM, and high tumor grade for NDM. Conclusion Our study suggested death of submandibular gland carcinoma occurred mainly due to distant metastasis. The significant predictors of distant metastasis were lymph node metastases (≥N2) and tumor grade (high grade).
Databáze: OpenAIRE
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