Baseline Predictors of Low-Density Lipoprotein Cholesterol and Systolic Blood Pressure Goal Attainment After 1 Year in the ISCHEMIA Trial
| Autor: | Sean M. O'Brien, Nagaraja Moorthy, Roxy Senior, Peter Stone, William E. Boden, Neeraj Pandit, Xiangqiong Gu, Jonathan D. Newman, Judith S. Hochman, Olga L. Bockeria, Sajeev Chakanalil Govindan, Gregg W. Stone, Jerome L. Fleg, Marcin Demkow, Gilbert Gosselin, David J. Maron, Jose Lopez-Sendon, Paulo Cury Rezende, John A. Spertus, Karen P. Alexander |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Heart disease Ischemia Low density lipoprotein cholesterol Blood Pressure Disease Coronary Artery Disease law.invention Sex Factors Randomized controlled trial Clinical Protocols law Risk Factors Internal medicine medicine Humans Risk factor Healthcare Disparities Antihypertensive Agents Aged Dyslipidemias Randomized Controlled Trials as Topic business.industry Age Factors Cholesterol LDL Health Status Disparities Middle Aged medicine.disease Goal attainment Blood pressure Hypertension Cardiology Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Circulation. Cardiovascular quality and outcomes. 12(11) |
| ISSN: | 1941-7705 |
| Popis: | Background: Risk factor control is the cornerstone of managing stable ischemic heart disease but is often not achieved. Predictors of risk factor control in a randomized clinical trial have not been described. Methods and Results: The ISCHEMIA trial (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) randomized individuals with at least moderate inducible ischemia and obstructive coronary artery disease to an initial invasive or conservative strategy in addition to optimal medical therapy. The primary aim of this analysis was to determine predictors of meeting trial goals for LDL-C (low-density lipoprotein cholesterol, goal Conclusions: In ISCHEMIA, older age, male sex, high-intensity statin use, lower baseline LDL-C, and North American location predicted 1-year LDL-C goal attainment, whereas lower baseline SBP and North American location predicted 1-year SBP goal attainment. Future studies should examine the effects of sex disparities, international practice patterns, and provider behavior on risk factor control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|