Endothelial dysfunction in Turkish patients with non-alcoholic fatty liver disease
| Autor: | O, Senturk, O, Kocaman, S, Hulagu, T, Sahin, C, Aygun, T, Konduk, A, Celebi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Brachial Artery Turkey Endothelium Gastroenterology Hyperaemia Internal medicine medicine.artery Internal Medicine medicine Humans Outpatient clinic Vascular Diseases Endothelial dysfunction Brachial artery business.industry Fatty liver Middle Aged medicine.disease Fatty Liver body regions medicine.anatomical_structure Case-Control Studies Female Endothelium Vascular Steatohepatitis Metabolic syndrome medicine.symptom business |
| Zdroj: | Internal Medicine Journal. 38:183-189 |
| ISSN: | 1444-0903 |
| DOI: | 10.1111/j.1445-5994.2007.01481.x |
| Popis: | Background: The components of the metabolic syndrome are closely related with endothelial dysfunction, which is a pathophysiological issue of cardiovascular diseases. Non-alcoholic fatty liver disease (NAFLD) is considered as one of the components of the metabolic syndrome. The aim of this study was to evaluate the endothelial-dependent dilatation (EDD) and endothelial-independent dilatation (EID) of the brachial artery in NAFLD. Methods: Fifteen non-alcoholic steatohepatitis (NASH), 17 patients with simple steatosis and 16 healthy subjects formed the study group. Non-alcoholic fatty liver disease group was composed of patients admitted to the gastroenterology outpatient clinic because of increased liver enzymes. Endothelial functions of the brachial artery were evaluated by vascular ultrasound. EDD was assessed by establishing reactive hyperaemia, and EID was determined by using sublingual nitrate. Results: No statistical difference for the basal diameter of brachial artery was found between the groups (P = 0.49). The values for EDD and EID were significantly different across all three groups (P |
| Databáze: | OpenAIRE |
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