Microalbuminuria and Serum Cystatin C in Prediction of Early-Renal Insufficiency in Children with Obesity
| Autor: | Ozlem Oz-Sig, Hakan Erdogan, Özlem Kara |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Adolescent Renal function Physical examination Type 2 diabetes urologic and male genital diseases Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030225 pediatrics Internal medicine Diabetes mellitus Albuminuria Humans Medicine Obesity Renal Insufficiency Cystatin C Child Creatinine medicine.diagnostic_test business.industry medicine.disease female genital diseases and pregnancy complications Diabetes Mellitus Type 2 chemistry Child Preschool Pediatrics Perinatology and Child Health Microalbuminuria Metabolic syndrome business Biomarkers 030217 neurology & neurosurgery Glomerular Filtration Rate |
| Zdroj: | The Indian Journal of Pediatrics. 87:1009-1013 |
| ISSN: | 0973-7693 0019-5456 |
| DOI: | 10.1007/s12098-020-03294-z |
| Popis: | Serum cystatin-C (SCysC) and microalbuminuria are well-recognized early markers of renal damage. This study aims to assess whether these early markers are elevated in children with obesity and normal serum creatinine (SCr). Pediatric patients diagnosed with obesity were included (n = 105, ages 4-18 y) in this study. The patients were divided into three groups as follows: solely obese, metabolic syndrome and type 2 diabetes. Serum cystatin-C, 24-h microalbuminuria, SCr and glomerular filtration rate (GFR) were evaluated in all patients. All patients were examined with history, physical examination, laboratory analysis and ultrasonography evaluation. The findings showed that renal function, GFR and SCr levels were normal in all patients. There was microalbuminuria in six patients and SCysC was elevated in eight patients. There were also both elevated SCysC and microalbuminuria in eight patients. Significant elevations of both microalbuminuria and SCysC were detected in cases with type 2 diabetes (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink