Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
| Autor: | Rayra Pereira Santiago, Sètondji Cocou Modeste Alexandre Yahouédéhou, Valma Maria Lopes Nascimento, Marilda Souza Goncalves, Rodrigo Mota de Oliveira, Cleverson Alves Fonseca, Caroline Conceição da Guarda, Camylla V. B. Figueiredo, Larissa Carneiro Rocha, Suellen Pinheiro Carvalho, Milena Magalhães Aleluia, Luciana Magalhães Fiuza |
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| Rok vydání: | 2020 |
| Předmět: |
Male
030204 cardiovascular system & hematology Linkage Disequilibrium Hemoglobins chemistry.chemical_compound 0302 clinical medicine Pathology RB1-214 Child Receptor medicine.diagnostic_test biology Prognosis Lipids Cholesterol 030220 oncology & carcinogenesis Female Proteoglycans lipids (amino acids peptides and proteins) medicine.symptom Research Article Adolescent Genotype Article Subject Immunology Inflammation Anemia Sickle Cell Polymorphism Single Nucleotide Young Adult 03 medical and health sciences Immune system medicine Humans Cell Proliferation business.industry Haplotype Cholesterol LDL Pneumonia Cell Biology Transforming growth factor beta Haplotypes chemistry biology.protein Lipid profile business Receptors Transforming Growth Factor beta Biomarkers Transforming growth factor |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2020 (2020) |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation. Polymorphisms in the transforming growth factor-beta receptor 3 (TGFBR3) gene have been linked to several inflammatory diseases. This study investigated associations between two TGFBR3 haplotypes and classical laboratory parameters, as well as clinical manifestations, in SCD. We found that individuals with the GG haplotype presented higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, non-HDL cholesterol, total proteins, and globulin than individuals with non-GG haplotypes. In addition, the GG haplotype was associated with a previous history of pneumonia. Individuals with the CGG haplotype presented increased plateletcrit, TC, LDL-C levels, and non-HDL cholesterol. The CCG haplotype was also associated with a previous history of pneumonia. Our findings suggest that individuals with the GG and CGG haplotypes of TGFBR3 present important alterations in lipid profile. |
| Databáze: | OpenAIRE |
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