The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling
| Autor: | Christopher R. Jacobs, An M. Nguyen, Yuan N. Young |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cell signaling
Mechanosensation QH301-705.5 Science Cilium Acetylation Sensory system Biology Bioinformatics Embryonic stem cell General Biochemistry Genetics and Molecular Biology Mechanosensing Primary cilia Local environment Mechanosensitive channels Biology (General) Adaptation General Agricultural and Biological Sciences Neuroscience Process (anatomy) Research Article |
| Zdroj: | Biology Open Biology Open, Vol 4, Iss 12, Pp 1733-1738 (2015) |
| ISSN: | 2046-6390 |
| Popis: | Mechanosensation is crucial for cells to sense and respond to mechanical signals within their local environment. While adaptation allows a sensor to be conditioned by stimuli within the environment and enables its operation in a wide range of stimuli intensities, the mechanisms behind adaptation remain controversial in even the most extensively studied mechanosensor, bacterial mechanosensitive channels. Primary cilia are ubiquitous sensory organelles. They have emerged as mechanosensors across diverse tissues, including kidney, liver and the embryonic node, and deflect with mechanical stimuli. Here, we show that both mechanical and chemical stimuli can alter cilium stiffness. We found that exposure to flow stiffens the cilium, which deflects less in response to subsequent exposures to flow. We also found that through a process involving acetylation, the cell can biochemically regulate cilium stiffness. Finally, we show that this altered stiffness directly affects the responsiveness of the cell to mechanical signals. These results demonstrate a potential mechanism through which the cell can regulate its mechanosensing apparatus. Summary: Primary cilia stiffness can be modulated, affecting the cellular responsiveness to mechanical signals. We identify a potential mechanism that regulates cellular mechanosensitivity. |
| Databáze: | OpenAIRE |
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