Insulin Resistance and β-Cell Function of Lean versus Overweight or Obese Filipino Patients with Newly Diagnosed Type 2 Diabetes Mellitus
| Autor: | Oliver Allan Dampil, Gabriel V. Jasul, Francesca Paula Bautista |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
β cell function type 2 diabetes mellitus Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Newly diagnosed 030204 cardiovascular system & hematology Overweight 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance insulin resistance Internal medicine medicine overweight obese beta-cell function business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus lean Anthropometry medicine.disease Obesity Blood pressure Original Article medicine.symptom business |
| Zdroj: | Journal of the ASEAN Federation of Endocrine Societies |
| ISSN: | 2308-118X 0857-1074 |
| Popis: | Objectives To compare the level of insulin resistance and β-cell function between lean and overweight/obese Filipino patients with newly diagnosed type 2 diabetes mellitus (T2DM). Methodology This was a cross-sectional analytical study including newly diagnosed T2DM Filipino patients from St. Luke’s Medical Center - Quezon City. The patients were classified as either lean or overweight/obese. Age, sex, smoking history, anthropometric measures and blood pressure were obtained. Insulin resistance and β-cell function were determined using the homeostasis model assessment (HOMA). The original model (HOMA1) and the updated model (HOMA2) were used. Results A total of 80 subjects were included. There were 40 subjects in each group. The overweight/obese subjects had significantly higher mean insulin resistance (HOMA1-IR 9.8±11.7, HOMA2-IR 3.0±2.0) compared to the lean group (HOMA1-IR 2.9±1.5, HOMA2-IR 1.3±0.5). This was consistent in both HOMA1 and HOMA2 (p-values=0.001 and |
| Databáze: | OpenAIRE |
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