Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure
| Autor: | Victor Yman, James Tuju, Michael T. White, Gathoni Kamuyu, Kennedy Mwai, Nelson Kibinge, Muhammad Asghar, Christopher Sundling, Klara Sondén, Linda Murungi, Daniel Kiboi, Rinter Kimathi, Timothy Chege, Emily Chepsat, Patience Kiyuka, Lydia Nyamako, Faith H. A. Osier, Anna Färnert |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Epidemiology Science Plasmodium falciparum Protozoan Proteins Antibodies Protozoan General Physics and Astronomy Models Biological Article Fluorescence General Biochemistry Genetics and Molecular Biology Cohort Studies Epitopes Young Adult parasitic diseases Humans Child Multidisciplinary Infectious-disease diagnostics Infant Antimicrobial responses General Chemistry Middle Aged Kenya Malaria Kinetics ROC Curve Child Preschool Antibody Formation Female Biomarkers |
| Zdroj: | Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Strengthening malaria surveillance is a key intervention needed to reduce the global disease burden. Reliable serological markers of recent malaria exposure could improve current surveillance methods by allowing for accurate estimates of infection incidence from limited data. We studied the IgG antibody response to 111 Plasmodium falciparum proteins in 65 adult travellers followed longitudinally after a natural malaria infection in complete absence of re-exposure. We identified a combination of five serological markers that detect exposure within the previous three months with >80% sensitivity and specificity. Using mathematical modelling, we examined the antibody kinetics and determined that responses informative of recent exposure display several distinct characteristics: rapid initial boosting and decay, less inter-individual variation in response kinetics, and minimal persistence over time. Such serological exposure markers could be incorporated into routine malaria surveillance to guide efforts for malaria control and elimination. Serological markers of recent Plasmodium falciparum infection could be useful to estimate incidence. Here, the authors identify a combination of five serological markers to detect exposure to infection within the previous three months with >80% sensitivity and specificity. |
| Databáze: | OpenAIRE |
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