Effect of probenecid on the pharmacokinetics of moxalactam
| Autor: | J D Wolny, Gordon Brier, Karen S. Israel, Karl A. DeSante, B L Hatcher |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male Urinary system Renal function Pharmacology Kidney urologic and male genital diseases Elimination rate constant Pharmacokinetics polycyclic compounds medicine Humans Drug Interactions Pharmacology (medical) Cephamycins Moxalactam Volume of distribution Probenecid Chemistry organic chemicals Middle Aged biochemical phenomena metabolism and nutrition Anti-Bacterial Agents Cephalosporins Kinetics Infectious Diseases medicine.anatomical_structure bacteria Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 21:58-61 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.21.1.58 |
| Popis: | The effects of probenecid on the pharmacokinetics of moxalactam were studied in normal volunteers administered a 2-min l-g intravenous infusion. The results showed that probenecid did not alter the plasma or urinary concentrations of moxalactam, its apparent volume of distribution, plasma elimination half-life, elimination rate constant, or plasma and renal clearances. Therefore, moxalactam appears to be eliminated primarily by the kidney via glomerular filtration. |
| Databáze: | OpenAIRE |
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