Clinical Presentation and Serologic Response during a Rabies Epizootic in Captive Common Vampire Bats (Desmodus rotundus)
| Autor: | Lex G. Medina-Magües, Crystal M. Gigante, Jorge E. Osorio, Lauren Greenberg, Ignacio Amezcua, Panayampalli Subbian Satheshkumar, James A. Ellison, Andres Velasco-Villa, Elizabeth A. Falendysz, Richard Griesser, Tonie E. Rocke, Elsa M. Cárdenas-Canales |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
030231 tropical medicine lcsh:Medicine Case Report medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Rabies vaccine medicine rabies virus Direct fluorescent antibody Epizootic General Immunology and Microbiology biology outbreak Rabies virus lcsh:R Public Health Environmental and Occupational Health Outbreak neutralizing antibody vampire bat biology.organism_classification medicine.disease Virology 030104 developmental biology Infectious Diseases Vampire bat Desmodus rotundus Rabies clinical signs medicine.drug |
| Zdroj: | Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 34 (2020) Tropical Medicine and Infectious Disease |
| ISSN: | 2414-6366 |
| Popis: | We report mortality events in a group of 123 common vampire bats (Desmodus rotundus) captured in México and housed for a rabies vaccine efficacy study in Madison, Wisconsin. Bat mortalities occurred in México and Wisconsin, but rabies cases reported herein are only those that occurred after arrival in Madison (n = 15). Bats were confirmed positive for rabies virus (RABV) by the direct fluorescent antibody test. In accordance with previous reports, we observed long incubation periods (more than 100 days), variability in clinical signs prior to death, excretion of virus in saliva, and changes in rabies neutralizing antibody (rVNA) titers post-infection. We observed that the furious form of rabies (aggression, hyper-salivation, and hyper-excitability) manifested in three bats, which has not been reported in vampire bat studies since 1936. RABV was detected in saliva of 5/9 bats, 2−5 days prior to death, but was not detected in four of those bats that had been vaccinated shortly after exposure. Bats from different capture sites were involved in two separate outbreaks, and phylogenetic analysis revealed differences in the glycoprotein gene sequences of RABV isolated from each event, indicating that two different lineages were circulating separately during capture at each site. |
| Databáze: | OpenAIRE |
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