Ontogeny and distribution of cells in B lineage in the American leopard frog, Rana pipiens
| Autor: | Leslie D. Zettergren |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Lineage (genetic) Lymphoid Tissue Surface Immunoglobulin Ontogeny Plasma Cells Immunology Receptors Antigen B-Cell Kidney Immunofluorescence Rana medicine Animals Antibody-Producing Cells B cell B-Lymphocytes medicine.diagnostic_test biology Rana pipiens Leopard frog Cell Differentiation biology.organism_classification Molecular biology medicine.anatomical_structure Immunoglobulin M Liver Immunoglobulin G Larva biology.protein Female Antibody Developmental Biology |
| Zdroj: | Developmental & Comparative Immunology. 6:311-320 |
| ISSN: | 0145-305X |
| DOI: | 10.1016/s0145-305x(82)80014-1 |
| Popis: | Two-color immunofluorescence techniques were used in order to trace the development and distribution of cells expressing immunoglobulin in Rana pipiens. Evidence is provided which suggests that (i) embryo-larval urogenital tissues are sites of generation of cells in B lineage, (ii) during ontogeny, there is a sequential expression of immunoglobulin isotypes on B cell surfaces, (iii) larvae are able to produce the full range of immunoglobulin clases found in adults, and (iv) at least two subpopulations of lymphocytes exist in Rana pipiens, sIg+ and sIg-; thymocytes and presumably peripheral T cells lack conventional surface immunoglobulin. Some ontogenetic and phylogenetic implications are discussed. |
| Databáze: | OpenAIRE |
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