Lymphocyte subsets, macrophages and Langerhans cells in actinomycetoma and eumycetoma tissue reaction
| Autor: | Claudia Cenci Guimarães, Luiz Guilherme Martins Castro, Mirian Nacagami Sotto |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Langerhans cell T-Lymphocytes Veterinary (miscellaneous) Population Biology Eumycetoma Immune system Antigen Antigens CD medicine Humans Macrophage education B-Lymphocytes education.field_of_study integumentary system Macrophages Middle Aged medicine.disease Immunohistochemistry Actinomycetoma Lymphocyte Subsets Infectious Diseases medicine.anatomical_structure Langerhans Cells Mycetoma Insect Science Immunology Female Parasitology CD8 |
| Zdroj: | Acta Tropica. 87:377-384 |
| ISSN: | 0001-706X |
| DOI: | 10.1016/s0001-706x(03)00139-6 |
| Popis: | The aim of this work was to demonstrate, quantify and compare cell elements in the inflammatory infiltrate of 23 skin lesions of actinomycetoma (ACM) and 17 of eumycetoma (EUM). Epidermal Langerhans cells (LC) population was also analyzed in 18 ACM, 13 EUM and ten normal skin samples as control group. Tissue response in both groups of mycetoma showed CD4 and CD8 T lymphocytes surrounding the neutrophils aggregates with macrophages, revealed by CD68 antibody, among them. B lymphocytes were not identified. ACM lesions showed a higher number of CD8+ lymphocytes (P=0.02) and macrophages (P=0.01) when compared with EUM lesions. As well as morphologically altered, displaying irregular and short dendritic processes, LC were depleted both in ACM and EUM lesions (P=0.0004) when compared with normal skin but no difference between both types of mycetoma (P>0.05) was found. Results suggest that cellular mediated immunity may play a role in mycetoma pathogenesis. The morphological alterations and marked reduction of LC in mycetoma lesions might reflect a depressed cellular immune response, partially explaining the chronic course and unresponsiveness to treatment of this group of diseases. |
| Databáze: | OpenAIRE |
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