Fasting improves tolerance to acute hypoxia in rats
Autor: | Xiang Zhou, Bo Jiao, Zhi-Bin Yu, Lin Zhang, Xiao-Ya Yue, Xiao-Bo Wang, Ru-Zhou Zhao, Shuai Jiang |
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Rok vydání: | 2021 |
Předmět: |
Male
Aging medicine.medical_specialty Blotting Western Biophysics Kaplan-Meier Estimate AMP-Activated Protein Kinases Biochemistry Mitochondrial Proteins Rats Sprague-Dawley chemistry.chemical_compound Animal model Simulated altitude Acute hypoxia Microscopy Electron Transmission Internal medicine Autophagy Animals Medicine Hypoxia Molecular Biology Survival rate Control treatment business.industry Myocardium Age Factors NF-kappa B Membrane Proteins AMPK NF-κB Fasting Cell Biology Adaptation Physiological Endocrinology chemistry Reactive Oxygen Species business Signal Transduction |
Zdroj: | Biochemical and Biophysical Research Communications. 569:161-166 |
ISSN: | 0006-291X |
Popis: | Acute high-altitude illness seriously threatens the health and lives of people who rapidly ascend to high altitudes, but there is currently no particularly effective method for the prevention or treatment of acute high-altitude illness. In the present study, we found that fasting preconditioning effectively improved the survival rate of rats exposed to a simulated altitude of 7620 m for 24 h, and a novel animal model of rapid adaptation to acute hypoxia was established. Compared with control treatment, fasting preconditioning activated AMPK, induced autophagy, decreased ROS levels, and inhibited NF-κB signaling in the cardiac tissues of rats. Our results suggested that fasting effectively improved the acute hypoxia tolerance of rats, which was gradually enhanced with prolongation of fasting. In addition, the acute hypoxia tolerance of young rats was significantly higher than that of adult rats. These experimental results lay the foundation for achieving rapid adaptation to acute hypoxia in humans. |
Databáze: | OpenAIRE |
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