Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico
| Autor: | Rosario García-Miranda, Ivan Delgado-Enciso, Adan Valladares-Salgado, César Antonio Irecta-Nájera, Pilar E Núñez Ortega, María E Meneses, Daniel Locia-Morales, Héctor Ochoa-Díaz-López, Itandehui Castro-Quezada, Elena Flores-Guillén, Roberto Solís-Hernández |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Physiology GN49-298 Alpha-Ketoglutarate-Dependent Dioxygenase FTO Human Factors and Ergonomics Single-nucleotide polymorphism Logistic regression Disease cluster Polymorphism Single Nucleotide Polymorphism (computer science) Physiology (medical) Humans SNP Medicine Orthopedics and Sports Medicine Mexico business.industry Mayan indigenous women Public Health Environmental and Occupational Health nutritional and metabolic diseases Single nucleotide polymorphisms Middle Aged Anthropometry medicine.disease Metabolic syndrome Genotype frequency Physical anthropology. Somatology Cross-Sectional Studies Anthropology Indians North American Original Article Female FTO business Chiapas Demography |
| Zdroj: | Journal of Physiological Anthropology, Vol 40, Iss 1, Pp 1-10 (2021) Journal of Physiological Anthropology |
| ISSN: | 1880-6805 |
| Popis: | Background Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas. Methods In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components. Results The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3–5.3; p = 0.007). Conclusions Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas. |
| Databáze: | OpenAIRE |
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