Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease
| Autor: | Thaddeus K. Weigel, Joshua A. Kulas, Heather A. Ferris |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Disease
Bioinformatics Article Diabetes Complications 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Alzheimer Disease Diabetes mellitus Drug Discovery Diabetes Mellitus medicine Humans Disease process Risk factor Cholesterol business.industry Neurodegeneration Lipid metabolism Lipid Metabolism medicine.disease chemistry 030220 oncology & carcinogenesis Disease Progression Insulin Resistance business 030217 neurology & neurosurgery |
| Zdroj: | Drug Dev Res |
| ISSN: | 1098-2299 0272-4391 |
| DOI: | 10.1002/ddr.21643 |
| Popis: | Diabetes disrupts organs throughout the body including the brain. Evidence suggests diabetes is a risk factor for Alzheimer's disease (AD) and neurodegeneration. In this review, we focus on understanding how diabetes contributes to the progression of neurodegeneration by influencing several aspects of the disease process. We emphasize the potential roles of brain insulin resistance, as well as cholesterol and lipid disruption, as factors which worsen AD. |
| Databáze: | OpenAIRE |
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