Abnormalities in fasting circulating proinsulin concentration in mild gestational diabetes
| Autor: | M. Davies, Robert S. Elkeles, Desmond G. Johnston, S. M. Hampton, Anne Dornhorst, R.W. Beard, V. Anyaoku |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Prohormone Pregnancy in Diabetics Endocrinology Pregnancy Internal medicine Diabetes mellitus medicine Humans Insulin Pancreatic hormone Proinsulin business.industry Fasting medicine.disease Gestational diabetes Diabetes Mellitus Type 2 Gestation Female business Body mass index medicine.drug |
| Zdroj: | Clinical endocrinology. 34(3) |
| ISSN: | 0300-0664 |
| Popis: | Fasting plasma proinsulin, insulin and glucose concentrations were measured in ten women with mild gestational diabetes and ten controls matched for race, age (32 +/- 6 vs 31 +/- 6 years), body mass index (28 +/- 8 vs 27 +/- 6) and gestational week (24 +/- 4 vs 25 +/- 4 weeks). There was no significant difference in fasting plasma glucose between these gestational diabetics and their controls (median 4.7, range 3.7-6.0 mmol/l vs 4.5, range 3.4-5.3 mmol/l). The fasting proinsulin levels were significantly higher in the gestational diabetics compared with the controls (median 12.2, range less than 4-14.8 pmol/l vs 5.8, range less than 4-12.8 pmol/l, P less than or equal to 0.02, Wilcoxon Summed Rank Test), while the calculated intact insulin levels (immunoreactive insulin minus proinsulin) were significantly lower (median 14.5, range 6.3-81.8 pmol/l vs 51.6, range 11.7-312 pmol/l, P less than or equal to 0.01). The ratio of proinsulin to calculated intact insulin was significantly higher in the gestational diabetics than the controls (median 0.66, range 0.16-2.04 vs 0.12, range 0.03-0.62), P less than or equal to 0.01). These results demonstrate that gestational diabetics, with normal fasting plasma glucose values, have abnormalities in pancreatic beta-cell secretion, which are likely to be important both in the aetiology of gestational diabetes and non-insulin dependent diabetes. |
| Databáze: | OpenAIRE |
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