COVID-19-Associated Multisystem Inflammatory Syndrome Complicated with Giant Coronary Artery Aneurysm
Autor: | Ali Sadeghi Lotfabadi, Leila Shahbaznejad, Mohammad Reza Navaeifar, Mohammad Sadegh Rezai |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Coronary artery aneurysm
medicine.medical_specialty business.industry Coronary artery ectasia Case Report General Medicine 030204 cardiovascular system & hematology medicine.disease Rash Gastroenterology Pediatrics RJ1-570 03 medical and health sciences Pneumonia 0302 clinical medicine Methylprednisolone Internal medicine medicine Kawasaki disease Medical history 030212 general & internal medicine Seroconversion medicine.symptom business medicine.drug |
Zdroj: | Case Reports in Pediatrics, Vol 2021 (2021) Case Reports in Pediatrics |
ISSN: | 2090-6811 2090-6803 |
Popis: | In the early stages of the outbreak of the novel coronavirus disease 2019 (COVID-19), it was assumed that this infection is very mild and uncommon in children. However, recent reports have shown that children may also develop the disease and its severe complications. These complications included shock, multisystem inflammatory syndrome in children (MIS-C), and pneumonia in children. A previously healthy 14-month-old boy presented with fever, irritability, and skin rash, besides changes in the lips, conjunctiva, and tongue. His medical history, clinical presentations, treatment, laboratory data, and follow-up information were recorded. He was treated according to the diagnosis of Kawasaki disease (KD). He had a history of close contact with a COVID-19 patient. However, the result of reverse transcription-polymerase chain reaction (RT-PCR) assay for COVID-19 was negative. Immunoglobulin M for COVID-19 was positive (1.20), while immunoglobulin G was negative (0.37). Three weeks later, seroconversion of COVID-19 immunoglobulin G (1.42) occurred. Despite treatment with two doses of intravenous immunoglobulin and methylprednisolone, coronary artery ectasia was detected. On the sixth day of hospitalization, the patient experienced hypotension, which necessitated treatment with inotropic drugs and resulted in a change of diagnosis to MIS-C. The later echocardiography showed evidence of coronary artery aneurysm (CAA), which finally changed to giant CAA. Although the patient was treated with infliximab, the size of CAA showed a significant decrease in the one-month follow-up. This is the first report of MIS-C during the COVID-19 pandemic in Iran, accompanied by KD, which was complicated with giant CAA. |
Databáze: | OpenAIRE |
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