Benzimidazole-based dual dipeptidyl peptidase-4 and xanthine oxidase inhibitors
| Autor: | Andrija Smelcerovic, Anelia Ts. Mavrova, Milan Kojic, Zaklina Smelcerovic, Katarina Tomovic, Denitsa Yancheva, Budimir S. Ilić, Marija Miljkovic, Gordana Kocic |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Dual inhibition Benzimidazole Xanthine Oxidase Dipeptidyl Peptidase 4 Pharmacology Toxicology 03 medical and health sciences chemistry.chemical_compound Structure-Activity Relationship 0302 clinical medicine Cell Line Tumor Ic50 values Humans Hypoglycemic Agents Xanthine oxidase Cytotoxicity Dipeptidyl peptidase-4 chemistry.chemical_classification Dipeptidyl-Peptidase IV Inhibitors Binding Sites General Medicine 3. Good health Molecular Docking Simulation 030104 developmental biology Enzyme chemistry Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Benzimidazoles Caco-2 Cells Reactive Oxygen Species |
| Zdroj: | Chemico-biological interactions. 315 |
| ISSN: | 1872-7786 |
| Popis: | Multiple-targeting compounds might reduce complex polypharmacy of multifactorial diseases, such as diabetes, and contribute to the greater therapeutic success. Targeting reactive oxygen species-producing enzymes, as xanthine oxidase (XO), might suppress progression of diabetes-associated vascular complications. In this study a small series of benzimidazole derivatives (1–9) was evaluated for inhibitory activity against dipeptidyl peptidase-4 (DPP-4) and XO. One 1,3-disubstituted-benzimidazole-2-imine (5) and 1,3-thiazolo[3,2-a]benzimidazolone derivative (8) were shown as effective dual DPP-4 and XO inhibitors, with IC50 values lower than 200 μM, and predicted binding modes with both target enzymes. Both selected dual inhibitors (compounds 5 and 8) did not show cytotoxicity to a greater extent on Caco-2 cells even at concentration of 250 μM. These structures represent new non-purine scaffolds bearing two therapeutic functionalities, being DPP-4 and XO inhibitors, more favorable in comparison to DPP-4 inhibitors with DPP-4 as a single target due to pleiotropic effects of XO inhibition. |
| Databáze: | OpenAIRE |
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