Immunohistochemical Comparison of the Expression of p53 and MDM2 Proteins in Ameloblastomas and Keratocystic Odontogenic Tumors
| Autor: | Shahab Babakoohi, Hamed Zartab, Habibollah Esmaili, Nasrollah Saghravanian, Nooshin Mohtasham, Maryam Zamanzadeh, Hamid Abbaszadeh-Bidokhty, Noorieh Sharifi-Sistani, Shokoofeh Jamshidi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Tumor suppressor gene Odontogenic Tumors medicine.disease_cause Ameloblastoma Pathogenesis medicine Humans Retrospective Studies biology business.industry Proto-Oncogene Proteins c-mdm2 General Medicine medicine.disease Immunohistochemistry Odontogenic Cross-Sectional Studies Otorhinolaryngology Lymphatic Metastasis Odontogenic Cysts Cancer research biology.protein Mdm2 Surgery Keratocystic Odontogenic Tumor Tumor Suppressor Protein p53 Carcinogenesis business |
| Zdroj: | Journal of Craniofacial Surgery. 22:1652-1656 |
| ISSN: | 1049-2275 |
| DOI: | 10.1097/scs.0b013e31823188e9 |
| Popis: | OBJECTIVE Ameloblastoma and keratocystic odontogenic tumor (KOT) is characterized by a benign but locally invasive behavior with a high risk of recurrence. MDM2 (murine double minute 2), an amplifier of cell proliferation, and p53, a tumor suppressor gene, are overexpressed in some odontogenic lesions. The aim of this study was to compare the expression of MDM2 and p53 in ameloblastoma and KOT as 2 lesions with similar biologic behavior, by immunohistochemistry. METHODS The expressions of MDM2 and p53 proteins were determined in 39 ameloblastomas (15 follicular types, 15 plexiform types, and 9 unicystic types) and 15 KOTs. RESULTS P53 protein was expressed in 100% of KOTs and 77.8% of ameloblastomas, and MDM2 was detected in 74.8% of ameloblastomas and 80% of KOTs. There was no statistical difference between MDM2 and p53 expressions in different subtypes of ameloblastomas and also when KOTs were compared with them (P > 0.05). There was a significant difference between immunohistochemical reactivity of MDM2 among subtypes of ameloblastomas (P < 0.05). MDM2 and p53 expressions were positively correlated. CONCLUSIONS Overexpression of p53 and MDM2 is associated with the pathogenesis and oncogenesis of ameloblastomas and KOT. Overexpression of these markers can contribute to similar biologic behavior of these lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|