Face memory in MRI-positive and MRI-negative temporal lobe epilepsy
| Autor: | Einar Goebell, B. Voges, Matthias Lindenau, Stefan Stodieck, Thomas Malina, Thomas Bengner |
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| Rok vydání: | 2006 |
| Předmět: |
Hippocampal sclerosis
Memory Disorders Long-term memory business.industry Memoria Recognition Psychology medicine.disease Magnetic Resonance Imaging Functional Laterality Temporal lobe Central nervous system disease Form Perception Epilepsy Neurology Epilepsy Temporal Lobe Face medicine Humans Neurology (clinical) Generalized epilepsy Nuclear medicine business Psychology Neuroscience Recognition memory |
| Zdroj: | Epilepsia. 47(11) |
| ISSN: | 0013-9580 |
| Popis: | Summary: Purpose: Effects of MRI-positive (MRI(+)) as compared to MRI-negative (MRI(−)) temporal lobe epilepsy (TLE) on face memory are not yet known. Methods: We studied 24 MRI(−) (11 right/13 left) and 20 MRI(+) (13 right/7 left) TLE patients, 12 generalized epilepsy patients, and 12 healthy subjects undergoing diagnostic workup with 24‐72-h Video-EEG-monitoring. Twenty faces were shown, and had to be recognized from 40 faces immediately and after a 24-h delay. Results: MRI(+) and MRI(−) right TLE (RTLE) patients showed deficits in face recognition compared to controls or generalized epilepsy, consistent with right temporal lobe dominance for face recognition. MRI(+) RTLE patients had deficits in both immediate and delayed recognition, while MRI(−) RTLE patients showed delayed recognition deficits only. The RTLE groups showed comparable delayed recognition deficits. Separate analyses in which the MRI(+) group included patients with hippocampal sclerosis only, did not alter results. Furthermore, MRI(−) RTLE had a worse delayed recognition than MRI(−) left TLE (LTLE). On the other hand, MRI(+) RTLE did not differ from MRI(+) LTLE in delayed recognition. Combining MRI(−) and MRI(+) TLE groups, we found differences between RTLE and LTLE in delayed, but not immediate face recognition. Conclusions: Our results suggest that a delayed recognition condition might be superior to immediate recognition tests in detecting face memory deficits in MRI(−) RTLE patients. This might explain why former studies in preoperative patients did not observe an immediate face recognition dominance of the right temporal lobe when combining MRI(−) and MRI(+) TLE patients. Our data further point to an important role of the right mesial temporal region in face recognition in TLE. Key Words: Cryptogenic—Lesional—Long-term memory—Right medial temporal lobe—Recognition memory. |
| Databáze: | OpenAIRE |
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