Anaplastic Large Cell Lymphoma with Oral Manifestation: A Series of Four Cases and Literature Review
| Autor: | Ana Luiza Oliveira Corrêa Roza, Mário José Romañach, Pablo Agustin Vargas, Maria Danielle C. Da Costa Fontes, Michelle Agostini, Denize D'Azambuja Ramos, Cristiane Bedran Milito, José Carlos Morais, Bruno Augusto Benevenuto de Andrade, Nathalie Henriques Silva Canedo |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty CD30 Adolescent H&E stain Pathology and Forensic Medicine 03 medical and health sciences Cytokeratin Young Adult 0302 clinical medicine hemic and lymphatic diseases Eosinophilic Oral and maxillofacial pathology medicine Humans Oral mucosa Anaplastic large-cell lymphoma Aged 80 and over Original Paper business.industry Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology Otorhinolaryngology 030220 oncology & carcinogenesis Lymphoma Large-Cell Anaplastic Female Mouth Neoplasms Differential diagnosis business |
| Zdroj: | Head Neck Pathol |
| ISSN: | 1936-0568 |
| Popis: | The aim of this study was to describe the clinicopathological and immunohistochemical features of four cases of anaplastic large cell lymphoma (ALCL) diagnosed through oral manifestations. Clinical data were collected from charts of a single oral pathology laboratory over a 5-year period (2014–2019) and all cases were evaluated by conventional hematoxylin and eosin staining and an extended immunohistochemical panel comprising CD45, CD20, CD3, CD4, CD7, CD30, CD99, CD138, cytokeratin AE1/AE3, EMA, ALK, MUM-1 and Ki-67. The study included 3 male (75%) and 1 female (25%) patients, with a median age of 44 years. The most common intraoral affected site was the alveolar ridge (50%). Clinically, all cases were characterized as an ulcerated bleeding mass. Microscopically, proliferation of anaplastic large lymphoid cells with medium to large-sized, abundant amphophilic to eosinophilic cytoplasm and eccentric nuclei were observed. All cases were positive for CD30, while two cases strongly express ALK. Two patients died of the disease. Careful correlation of clinical, morphological and immunohistochemical data are necessary to establish the diagnosis of oral manifestation of ALCL since its microscopical features may mimic other malignant tumors. Clinicians and pathologists should consider ALCL in the differential diagnosis when evaluating oral ulcerated swellings exhibiting large lymphoid cells in patients with lymphadenopathy. |
| Databáze: | OpenAIRE |
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