Digoxin-like immunoreactivity in Chinese medicine
| Autor: | J Tachi, M Yasuhara, Kiyoshi Miyai, Shigeru Iyama, Taichin Koh, Fushimi R, Kazuma Kohda, Nobuyuki Amino |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pharmacology
Cardiotonic steroids Digoxin Time Factors Traditional medicine medicine.diagnostic_test business.industry Drug Compounding Traditional Chinese medicine Cross Reactions Trypsin like enzyme Therapeutic drug monitoring Healthy volunteers polycyclic compounds Medicine Humans Pharmacology (medical) In patient cardiovascular diseases Medicine Chinese Traditional business medicine.drug |
| Zdroj: | Therapeutic drug monitoring. 12(3) |
| ISSN: | 0163-4356 |
| Popis: | Immunoreactive digoxin-like activity was observed in Chinese medicine, KYUSHIN tablet, taken popularly in Japan without prescription. The antibodies used in the assays of digoxin reacted with Chan-su, the major effective component of KYUSHIN, which contained cardiotonic steroids with similar chemical structure as digoxin. One tablet of KYUSHIN had digoxin-like immunoreactivity equivalent to 1.9, 1.5, and 72 micrograms of digoxin measured by three different commercial kits. These different equivalences may be attributed to differences in cross-reactivity of the antibody used in the immunoassays. Two healthy volunteers took two KYUSHIN tablets three times a day, a typical dose, and digoxin-like immunoreactivity reached almost 0.4 micrograms/L in 0.5 day. Therapeutic drug monitoring should be interpreted carefully in patients taking Chinese medicines, many of which contain the Chan-su component. |
| Databáze: | OpenAIRE |
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