Spotlight on biodiversity of microbial cell factories for glycerol conversion
| Autor: | Denis Kalemasi, Hannes Russmayer, Michael Sauer, Michael Egermeier |
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| Rok vydání: | 2019 |
| Předmět: |
Glycerol
0106 biological sciences Microorganism Carbohydrates Microbial metabolism Bioengineering 01 natural sciences Applied Microbiology and Biotechnology Metabolic engineering Industrial Microbiology 03 medical and health sciences chemistry.chemical_compound 010608 biotechnology 1 3-Propanediol Oleochemistry 030304 developmental biology 0303 health sciences Biodiversity Industrial microbiology Pulp and paper industry Metabolic Engineering chemistry Bioprocess engineering Environmental science Biotechnology |
| Zdroj: | Biotechnology Advances. 37:107395 |
| ISSN: | 0734-9750 |
| DOI: | 10.1016/j.biotechadv.2019.05.001 |
| Popis: | Plant oil based industrial oleochemistry leads to a large side stream of crude glycerol, which offers itself as a low price carbon source for microbial chemical production. Compared to sugar, glycerol is more reduced and less microorganisms are able to use it as carbon source. An interesting feature of glycerol conversion is that many organisms cannot use it as carbon source at all, but they readily use it as electron sink under anaerobic conditions. In any case the number of pathways by which glycerol enters the microbial metabolism is quite limited. Having said this, an interesting variety of products of industrial relevance is accumulated by naturally occurring microorganisms which can use glycerol. These chemicals range from fuels and solvents to polymer precursors up to food additives. The limited number of metabolic pathways and the manageable amount of products allow to highlight the importance of tapping the outstanding resource of biodiversity for industrial purposes. The interplay of microbial biodiversity, metabolic engineering and bioprocess engineering is key for economic success in industrial microbiology. In this article we shed light on the biodiversity of naturally glycerol consuming microorganisms and their impact and importance on microbial chemical production. |
| Databáze: | OpenAIRE |
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