Obesity alters the gustatory perception of lipids in the mouse: plausible involvement of lingual CD36. : Obesity decreases the fat preference
| Autor: | Déborah Ancel, Arnaud Bernard, Michael Chevrot, Isabelle Niot, Marjorie Buttet, Philippe Besnard, Souleymane Abdoul-Azize, Céline Martin, Jean-François Merlin, Naim Akhtar Khan, Hélène Poirier, Patricia Passilly-Degrace |
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| Přispěvatelé: | Physiologie de la Nutrition et Toxicologie (NUTox) (U866, Lipides et nutrition, équipe 7) (NUTox), Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Burgundy Council and Centre National Interprofessionnel de l'Economie Laitière (CNIEL) (HumanFATaste program), FUI SYMPPA, Physiologie de la Nutrition et Toxicologie (NUTox) (U866, Lipides et nutrition, équipe 7) ( NUTox ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
CD36 Antigens
CD36 [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition Adipose tissue MESH : Behavior Animal Biochemistry Calcium in biology Mice 0302 clinical medicine Endocrinology MESH : Calcium Signaling MESH: Behavior Animal MESH: Obesity MESH: Animals Lingual papilla Research Articles 2. Zero hunger 0303 health sciences MESH : Food Preferences Behavior Animal MESH : Tongue MESH : Diet High-Fat MESH: Tongue Taste Perception taste sensitivity MESH : Antigens CD36 calcium imaging Adipose Tissue Health MESH: Dietary Fats MESH : Obesity Fat taste MESH: Adipose Tissue medicine.medical_specialty Food behavior 030209 endocrinology & metabolism MESH : Mice Inbred C57BL QD415-436 Biology Diet High-Fat MESH: Calcium Signaling MESH : Adipose Tissue Food Preferences 03 medical and health sciences Calcium imaging Tongue Downregulation and upregulation MESH: Mice Inbred C57BL Internal medicine MESH : Mice medicine Animals Calcium Signaling Obesity Fatty acids MESH: Food Preferences MESH: Mice 030304 developmental biology Nutrition long-chain fatty acids MESH: Antigens CD36 MESH : Taste Perception Cell Biology medicine.disease Dietary Fats Mice Inbred C57BL MESH: Diet High-Fat MESH: Taste Perception biology.protein MESH : Animals Body mass index [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition MESH : Dietary Fats |
| Zdroj: | Journal of Lipid Research Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2013, 54 (9), pp.2485-94. ⟨10.1194/jlr.M039446⟩ Journal of Lipid Research, Vol 54, Iss 9, Pp 2485-2494 (2013) Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2013, 54 (9), pp.2485-94. 〈10.1194/jlr.M039446〉 |
| ISSN: | 0022-2275 |
| DOI: | 10.1194/jlr.M039446⟩ |
| Popis: | International audience; A relationship between orosensory detection of dietary lipids, regulation of fat intake, and body mass index was recently suggested. However, involved mechanisms are poorly understood. Moreover, whether obesity can directly modulate preference for fatty foods remains unknown. To address this question, exploration of the oral lipid sensing system was undertaken in diet-induced obese (DIO) mice. By using a combination of biochemical, physiological, and behavioral approaches, we found that i) the attraction for lipids is decreased in obese mice, ii) this behavioral change has an orosensory origin, iii) it is reversed in calorie-restricted DIO mice, revealing an inverse correlation between fat preference and adipose tissue size, iv) obesity suppresses the lipid-mediated downregulation of the lipid-sensor CD36 in circumvallate papillae, usually found during the refeeding of lean mice, and v) the CD36-dependent signaling cascade controlling the intracellular calcium levels ([Ca(2+)]i) in taste bud cells is decreased in obese mice. Therefore, obesity alters the lipid-sensing system responsible for the oral perception of dietary lipids. This phenomenon seems to take place through a CD36-mediated mechanism, leading to changes in eating behavior. |
| Databáze: | OpenAIRE |
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