Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions
| Autor: | Agata Lampart, Jakub Sławski, Katarzyna Dominika Sluzalska, Malgorzata Zakrzewska, Jacek Otlewski, Martyna Sochacka |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell signaling Endosome Chemistry Endocrinology Diabetes and Metabolism Immunology Fibroblast growth factor General Biochemistry Genetics and Molecular Biology Protein–protein interaction Cell biology Fibroblast Growth Factors 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Nucleocytoplasmic Transport 030220 oncology & carcinogenesis Fibroblast Growth Factor 1 Immunology and Allergy Fibroblast Growth Factor 2 Secretion Carrier Proteins Cytoskeleton Intracellular Signal Transduction |
| Zdroj: | Cytokine & Growth Factor Reviews. 57:93-111 |
| ISSN: | 1359-6101 |
| Popis: | Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are able to translocate from the endosome to the cell interior. These unique features, as well as the role of the intracellular pool of FGF1 and FGF2, are far from being fully understood. An increasing number of reports address this problem, focusing on the intracellular interactions of FGF1 and 2. Here, we summarize the current state of knowledge of the FGF1 and FGF2 binding partners inside the cell and the possible role of these interactions. The partner proteins are grouped according to their function, including proteins involved in secretion, cell signaling, nucleocytoplasmic transport, binding and processing of nucleic acids, ATP binding, and cytoskeleton assembly. An in-depth analysis of the network of these binding partners could indicate novel, non-classical functions of FGF1 and FGF2 and uncover an additional level of a fine control of the well-known FGF-regulated cellular processes. |
| Databáze: | OpenAIRE |
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