Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise
| Autor: | Javier Díaz-Castro, Jorge Moreno-Fernandez, Julio J. Ochoa, Luis Javier Chirosa, Rafael Guisado, I.J. Chirosa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male High-intensity exercise Ubiquinone 030204 cardiovascular system & hematology Hematocrit Metabolic equivalent Basal (phylogenetics) chemistry.chemical_compound Hemoglobins 0302 clinical medicine Hematological parameters Chemokine CCL2 Fatigue ergogenic effect Nutrition and Dietetics medicine.diagnostic_test ubiquinol Cytokines Intercellular Signaling Peptides and Proteins Female medicine.symptom Inflammation Mediators lcsh:Nutrition. Foods and food supply Signal Transduction medicine.medical_specialty Ubiquinol hematological parameters Physical exercise Inflammation lcsh:TX341-641 high intensity exercise Article 03 medical and health sciences Oxygen Consumption Double-Blind Method Internal medicine medicine Humans Muscle Skeletal Exercise business.industry Sports anemia 030104 developmental biology Endocrinology chemistry inflammation Erythrocyte Count Exercise Test Hemoglobin Ergogenic effect business Food Science Interleukin-1 |
| Zdroj: | Nutrients Volume 12 Issue 2 Nutrients, Vol 12, Iss 2, p 424 (2020) Digibug. Repositorio Institucional de la Universidad de Granada instname |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12020424 |
| Popis: | Strenuous exercise (any activity that expends six metabolic equivalents per minute or more causing sensations of fatigue and exhaustion to occur, inducing deleterious effects, affecting negatively different cells), induces muscle damage and hematological changes associated with high production of pro-inflammatory mediators related to muscle damage and sports anemia. The objective of this study was to determine whether short-term oral ubiquinol supplementation can prevent accumulation of inflammatory mediators and hematological impairment associated to strenuous exercise. For this purpose, 100 healthy and well-trained firemen were classified in two groups: Ubiquinol (experimental group), and placebo group (control). The protocol was two identical strenuous exercise tests with rest period between tests of 24 h. Blood samples were collected before supplementation (basal value) (T1), after supplementation (T2), after first physical exercise test (T3), after 24 h of rest (T4), and after second physical exercise test (T5). Hematological parameters, pro- and anti-inflammatory cytokines and growth factors were measured. Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased. Ubiquinol supplementation during high intensity exercise could modulate inflammatory signaling, expression of pro-inflammatory, and increasing some anti-inflammatory cytokines. During exercise, RBC, hemoglobin, hematocrit, VEGF, and EGF increased in ubiquinol group, revealing a possible pro-angiogenic effect, improving oxygen supply and exerting a possible protective effect on other physiological alterations. |
| Databáze: | OpenAIRE |
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