Survey of the erythrocyte EPA+DHA levels in the heart attack/stroke belt
| Autor: | William S. Harris, Nathan L. Tintle, Kristina Harris Jackson, James T Brenna, L. Cornish, Judith C. Rodriguez |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Erythrocytes Docosahexaenoic Acids Fingerstick Clinical Biochemistry Myocardial Infarction 030209 endocrinology & metabolism Disease Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine SNP Humans Stroke Belt Aged 030109 nutrition & dietetics business.industry Cell Biology Fish oil Nutrition Surveys Eicosapentaenoic acid United States Stroke Eicosapentaenoic Acid Docosahexaenoic acid Cohort Female business |
| Zdroj: | Prostaglandins, leukotrienes, and essential fatty acids. 148 |
| ISSN: | 1532-2823 |
| Popis: | The Omega-3 Index (O3I; erythrocyte EPA+DHA as a percent of total fatty acids) is inversely related to risk for cardiovascular disease (CVD). The cardioprotective target O3I is 8%-12%. O3I levels in American regions with high CVD risk are poorly characterized.To determine the O3I in individuals participating in a Seafood Nutrition Partnership (SNP) survey in seven US cities in the CVD "belt."Fingerstick blood samples were analyzed for the O3I.The SNP cohort (n = 2177) had a mean (SD) O3I of 4.42% (1.12%). Only 1.2% were in the desirable range, whereas 42% had an undesirable (4%) O3I. The mean (SD) O3I in a subset of 772 SNP subjects who were matched for age and sex with the Framingham study was 4.6% (1.2%) compared 5.3% (1.6%) in the Framingham cohort (p 0.0001).Individuals in the CVD "belt" had relatively low O3I levels. Since in other settings, a low O3I is associated with increased risk for CVD, this may be one factor contributing to the higher risk for CVD in this region of the US. |
| Databáze: | OpenAIRE |
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