Bone Matrix Levels of Dickkopf and Sclerostin are Positively Correlated with Bone Mass and Strength in Postmenopausal Osteoporosis
| Autor: | Lis Stilgren, Jens Bollerslev, Thor Ueland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
sclerostin lcsh:Chemistry chemistry.chemical_compound 0302 clinical medicine Bone Density lcsh:QH301-705.5 Osteoporosis Postmenopausal Spectroscopy Bone mineral biology Wnt signaling pathway General Medicine Middle Aged VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710 Computer Science Applications medicine.anatomical_structure Bone Morphogenetic Proteins Osteocalcin Intercellular Signaling Peptides and Proteins Female Genetic Markers musculoskeletal diseases medicine.medical_specialty 030209 endocrinology & metabolism Bone morphogenetic protein Article Catalysis Inorganic Chemistry postmenopausal osteoporosis 03 medical and health sciences Dickkopf-1 Internal medicine medicine Humans bone matrix Physical and Theoretical Chemistry Molecular Biology Adaptor Proteins Signal Transducing Aged Femoral neck bone mass business.industry Organic Chemistry VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710 Wnt signaling 030104 developmental biology Endocrinology DKK1 chemistry lcsh:Biology (General) lcsh:QD1-999 biology.protein Sclerostin Cortical bone business |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 12, p 2896 (2019) Ueland, T, Stilgren, L & Bollerslev, J 2019, ' Bone Matrix Levels of Dickkopf and Sclerostin are Positively Correlated with Bone Mass and Strength in Postmenopausal Osteoporosis ', International Journal of Molecular Sciences, vol. 20, no. 12, 2896 . https://doi.org/10.3390/ijms20122896 International Journal of Molecular Sciences Volume 20 Issue 12 |
| ISSN: | 1422-0067 |
| Popis: | Wnt signaling plays a pivotal role in maintaining bone mass. Secreted pathway modulators such as sclerostin (SOST) and Dickkopfs (DKKs) may influence bone mass inhibiting the canonical Wnt pathway. We evaluated whether bone protein content of secreted Wnt antagonists is related to age, bone mass, and strength in postmenopausal osteoporosis. We measured cortical and trabecular bone contents of SOST and Dickkopf-1 (DKK1) in combined extracts obtained after ethylenediaminetetraacetic acid and guanidine hydrochloride extraction in 56 postmenopausal women aged 47&ndash 74 (mean, 63) yr with a previous distal forearm fracture and a hip or spine Z-score less than 0. Our findings were (i) SOST and DKK1 protein levels were higher in trabecular bone, (ii) cortical and trabecular DKK1 and trabecular SOST correlated positively with bone matrix levels of osteocalcin (r between 0.28 and 0.45, p < 0.05), (iii) cortical DKK1 correlated with lumbar spine bone mineral density (BMD) (r = 0.32, p < 0.05) and femoral neck BMD (r = 0.41, p < 0.01), and (iv) cortical DKK1 and SOST correlated with apparent bone volumetric density and compressive strength (r between 0.34 and 0.51, p < 0.01). In conclusion, cortical bone matrix levels of DKK1 and SOST were positively correlated with bone mass and bone strength in postmenopausal osteoporotic women. |
| Databáze: | OpenAIRE |
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