Is intrinsic lumbar spine shape associated with lumbar disc degeneration? An exploratory study
| Autor: | Jennifer S. Gregory, Alison H. McGregor, Adrian Lim, JA Deane, Pavlova Av, Richard M. Aspden |
|---|---|
| Přispěvatelé: | Arthritis Research UK |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Quality of life medicine.medical_specialty Statistical shape modelling Supine position lcsh:Diseases of the musculoskeletal system Lordosis Intervertebral Disc Degeneration 03 medical and health sciences 0302 clinical medicine Lumbar Rheumatology Lumbar disc degeneration Medicine Humans Orthopedics and Sports Medicine Low back pain Intervertebral Disc Aged 030203 arthritis & rheumatology Orthodontics Lumbar Vertebrae Models Statistical business.industry 1103 Clinical Sciences Lumbar Curve Middle Aged medicine.disease Magnetic Resonance Imaging Sagittal plane Orthopedics medicine.anatomical_structure Orthopedic surgery Female Analysis of variance medicine.symptom lcsh:RC925-935 business 030217 neurology & neurosurgery Research Article MRI |
| Zdroj: | BMC Musculoskeletal Disorders BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-10 (2020) Deane, J A, Pavlova, A V, Lim, A K P, Gregory, J S, Aspden, R M & McGregor, A H 2020, ' Is intrinsic lumbar spine shape associated with lumbar disc degeneration? An exploratory study ', BMC Musculoskeletal Disorders, vol. 21, no. 1, pp. 433 . https://doi.org/10.1186/s12891-020-03346-7 |
| ISSN: | 1471-2474 |
| Popis: | Background: Lumbar disc degeneration (LDD) is a condition associated with recurrent low back pain (LBP). Knowledge regarding effective management is limited. As a step towards the identification of risk, prognostic or potentially modifiable factors in LDD patients, the aim of this study was to explore the hypothesis that intrinsic lumbar spine shape is associated with LDD and clinical outcomes in symptomatic adults. Methods: 3 T MRI was used to acquire T2-weighted sagittal images (L1-S1) from 70 healthy controls and LDD patients (mean age 49 years, SD 11, range 31-71 years). Statistical Shape Modelling (SSM) was used to describe lumbar spine shape. SSM identified variations in lumbar shape as 'modes' of variation and quantified deviation from the mean. Intrinsic shape differences were determined between LDD groups using analysis of variance with post-hoc comparisons. The relationship between intrinsic shape and self-reported function, mental health and quality of life were also examined. Results: The first 7 modes of variation explained 91% of variance in lumbar shape. Higher LDD sum scores correlated with a larger lumbar lordosis (Mode 1 (55% variance), P = 0.02), even lumbar curve distribution (Mode 2 (12% variance), P = 0.05), larger anterior-posterior (A-P) vertebral diameter (Mode 3 (10% variance), P = 0.007) and smaller L4-S1 disc spaces (Mode 7 (2% variance), P ≤ 0.001). In the presence of recurrent LBP, LDD was associated with a larger A-P vertebral diameter (Mode 3) and a more even lumbar curvature with smaller L5/S1 disc spaces (Mode 4), which was significantly associated with patient quality of life (P = 0.002-0.04, rp = 0.43-0.61)). Conclusions: This exploratory study provides new evidence that intrinsic shape phenotypes are associated with LDD and quality of life in patients. Longitudinal studies are required to establish the potential role of these risk or prognostic shape phenotypes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink