Salvage treatment against human immunodeficiency virus
| Autor: | L. Sponagel, Manuel Battegay, Thomas Harr |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Drug
medicine.medical_specialty Anti-HIV Agents media_common.quotation_subject Salvage therapy HIV Infections Antiviral Agents Acquired immunodeficiency syndrome (AIDS) medicine Humans HIV Protease Inhibitor Protease inhibitor (pharmacology) Treatment Failure Viremia Intensive care medicine media_common Salvage Therapy Clinical Trials as Topic biology Drug Resistance Microbial HIV Protease Inhibitors General Medicine Viral Load biology.organism_classification medicine.disease Drug Resistance Multiple Drug Combinations Lentivirus Immunology HIV-1 Viral disease Viral load |
| Zdroj: | Annals of Medicine. 31:253-260 |
| ISSN: | 1365-2060 0785-3890 |
| Popis: | Despite dramatic declines in human immunodeficiency virus (HIV)-associated morbidity and mortality as a result of highly active antiretroviral combination therapies, including protease inhibitors, treatment failure occurs at such high rates as 20-50%. As drug regimens are very demanding, even short decreases of drug concentrations may trigger resistance. Viral loads can be decreased to very low concentrations, and there is no strict cut-off regarding the definition of treatment failure. Nevertheless, continuous detection of HIV of more than 50 copies per mL blood plasma is a predictor of increasing viral loads and of a suboptimal response to therapy. From a theoretical point of view, treatment changes should be made at low HIV RNA levels, but fewer options often dictate a more conservative approach. Drug susceptibility testing will be of increasing value, especially in patients experiencing drug failure for the first time. Success of salvage therapies is closely connected with the use of new compounds including new drug classes. As drugs susceptible to a multi-drug-resistant HIV are not yet available, regimens with more than three or even with five to nine drugs are used in clinical trials. Salvage therapies often fail in virological terms, ie in 50-80% of patients, depending primarily on the treatment history, but immunological and clinical stability can often be achieved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|