Structural comparison, physicochemical properties, and in vitro release profile of curcumin-loaded lyotropic liquid crystalline nanoparticle: Influence of hydrotrope as interface stabilizers
| Autor: | Alessandra Candida Rios, Fernando Batain, Katiusca da Silva Pontes, Kessi Marie de Moura Crescencio, Daniel Komatsu, Thais Francine Ribeiro Alves, Cecilia Torqueti de Barros, Eliana B. Souto, Juliana Ferreira de Souza, Marco Vinícius Chaud, Patrícia Severino, Moema Hausen, Venancio Alves Amaral |
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| Přispěvatelé: | Universidade do Minho |
| Rok vydání: | 2020 |
| Předmět: |
Curcumin
animal structures 02 engineering and technology Confocal scanning microscopy 010402 general chemistry 01 natural sciences Lyotropic Materials Chemistry Lamellar structure Physical and Theoretical Chemistry Spectroscopy Science & Technology urogenital system Chemistry Hydrotrope technology industry and agriculture Mesophase Poloxamer 021001 nanoscience & nanotechnology Condensed Matter Physics Lyotropic liquid crystal Controlled release Atomic and Molecular Physics and Optics 3. Good health 0104 chemical sciences Electronic Optical and Magnetic Materials Chemical engineering Hydrotropes 13. Climate action Nanoparticles Biomimetic system 0210 nano-technology |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2020.112861 |
| Popis: | Lyotropic liquid crystal (LLC) is a nano-biomimetic lipid-based system, which has thermodynamic property that is peculiar to it, and suitable for its structural ordering, which facilitates more intimate contact with the tissues. The LLC as a carrier of curcumin has been much studied, however, this is the first time that hydrotrope method approach has been used in the lamellar system precursor of the LLC nanoparticles (LLC-NPs). Curcumin was used due to its pharmacological properties. However, bioavailability is limited by poor water solubility, high chemical instability and metabolic susceptibility. The aim of this study was developed and lipid-based LLC systems prepared by the hydrotrope method were evaluated. Unlike most studies, sodium lauryl sulphate and Poloxamer 407® were used as hydrotropes and the stability, dissolution rate, and physicochemical properties of LLC-NPs were evaluated. The analysis of results showed that hydrotropes increase the stability of LLC-NPs and modify the curcumin release profile. The structural ordering of the lamellar mesophase and LLC-NPs was revealed by microscopy of polarized light and laser confocal scanning microscopy, the results showed a structure with the maltese cross. The LLC-NPs arising from lamellar mesophase with hydrotropes into water-lipid matrices hosted curcumin in the hilum of the maltese cross, and controlled release of curcumin. This study had financial support from CAPES/PROSUP-Brazil. We thank Kerry (Brazil) for supplying the raw material (Myverol® 18- 92K). We thank Prof. Dr. Fabio Leite responsible for the Department of Physics, Chemistry, and Mathematics/Postgraduate Program in Biotechnology and Environmental Monitoring located at the Federal University of São Carlos in Sorocaba/SP-Brazil and Prof. Dr. Moema de Alencar Hausen by analysis of structural characterization by laser confocal scanning microscopy. We thank Laboratory of Biomaterials, Pontificial University Catholic (PUC/SP-Brazil) and Prof. Dr. Daniel Komatsu by analysis of structural characterization by polarized light microscopy info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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