Validation of the flash-evoked response from fetal MEG
| Autor: | Jack McCubbin, Jiri Vrba, T. Yee, Stephen E. Robinson, Hubert Preissl, Pam Murphy, Hari Eswaran |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Photic Stimulation
Computer science Speech recognition Image processing Sensitivity and Specificity Article Signal-to-noise ratio medicine Humans Radiology Nuclear Medicine and imaging Fetal head Diagnosis Computer-Assisted Latency (engineering) Fetal Monitoring Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Brain Magnetoencephalography Reproducibility of Results Pattern recognition Signal-to-noise ratio (imaging) Evoked Potentials Visual Artificial intelligence business Algorithms |
| Zdroj: | Physics in Medicine and Biology. 52:5803-5813 |
| ISSN: | 1361-6560 0031-9155 |
| Popis: | Flash-evoked responses can be recorded from the fetus in utero. However, a standard analysis approach based on orthogonal projection (OP) to attenuate maternal and fetal cardiac signals leads to a spatial redistribution of the signal. This effect prevents the correlation of source location with a known fetal head location in some cases and the signal-to-noise ratio (SNR) is sometimes limited such that the response latency is difficult to determine. We used a modified beamformer model search analysis to avoid the redistribution shortcoming and to improve the SNR. We included a statistical test for residual interference in the average and quantified significance of the evoked response with a bootstrap method. Selected source locations compared favorably to fetal head locations estimated from ultrasound exams. The evoked response time course was found to have a significant post-trigger peak with a latency between about 180 and 770 ms in more than 90% of the subject measurements. These results confirm that the combined application of a beamformer model search and bootstrap significance test provides a validation of the flash-evoked response observed in OP processed fetal MEG channels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|