Electroosmotic flow analysis of a branched U-turn nanofluidic device
| Autor: | Anton P. Markesteijn, V.G. Kutchoukov, Ian T. Young, O.M. Piciu, Yuval Garini, Andre Bossche, Gea Oswah Fatah Parikesit, Jerry Westerweel |
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| Rok vydání: | 2005 |
| Předmět: |
Osmosis
Time Factors Surface Properties Microfluidics Static Electricity Biomedical Engineering Analytical chemistry Electro-osmosis Bioengineering Biochemistry Physics::Fluid Dynamics Diffusion Complex geometry Turn (geometry) Microscopy Electrochemistry Nanotechnology Computer Simulation Poisson Distribution Diffusion (business) Brownian motion Models Statistical Chemistry General Chemistry Mechanics Microfluidic Analytical Techniques Models Theoretical Flow (mathematics) Microscopy Fluorescence |
| Zdroj: | Lab on a chip. 5(10) |
| ISSN: | 1473-0197 |
| Popis: | In this paper, we present the analysis of electroosmotic flow in a branched -turn nanofluidic device, which we developed for detection and sorting of single molecules. The device, where the channel depth is only 150 nm, is designed to optically detect fluorescence from a volume as small as 270 attolitres (al) with a common wide-field fluorescent setup. We use distilled water as the liquid, in which we dilute 110 nm fluorescent beads employed as tracer-particles. Quantitative imaging is used to characterize the pathlines and velocity distribution of the electroosmotic flow in the device. Due to the device's complex geometry, the electroosmotic flow cannot be solved analytically. Therefore we use numerical flow simulation to model our device. Our results show that the deviation between measured and simulated data can be explained by the measured Brownian motion of the tracer-particles, which was not incorporated in the simulation. |
| Databáze: | OpenAIRE |
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