Tobacco-use behavior and toxicant exposure among current dual users of electronic cigarettes and tobacco cigarettes
Autor: | Megan Scott, Alyssa K Rudy, Rebecca C Lester, Amanda L. Graham, Thomas Eissenberg, Alison J. Montpetit, Makeda K. Austin, Caroline O. Cobb, Cosima Hoetger, Andrew J. Barnes, Thokozeni Lipato |
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Rok vydání: | 2020 |
Předmět: |
Tobacco use
Cigarette use Electronic Nicotine Delivery Systems Article law.invention Nicotine chemistry.chemical_compound Expired air Tobacco Use Cigarette smoking law Environmental health Tobacco medicine Humans Pharmacology (medical) Pharmacology Smokers business.industry Tobacco Products Psychiatry and Mental health chemistry Cotinine business Electronic cigarette Laboratories Clinical medicine.drug Toxicant |
Zdroj: | Exp Clin Psychopharmacol |
ISSN: | 1936-2293 |
Popis: | Electronic cigarette (e-cigarette) use continues to grow with most users reporting concurrent cigarette smoking, but few studies have focused on tobacco use and toxicant exposure among naturalistic dual-using populations. This controlled clinical laboratory study examined how dual versus exclusive use of e-cigarettes and cigarettes and no tobacco/nicotine affected behavioral, physiological, and subjective measures among current dual users. Twenty-two participants identifying as cigarette (≥ 10 cigarettes per day [CPD]) and e-cigarette (≥ 3 days/week) users of "cig-a-like" e-cigarettes completed four 5-day outpatient conditions, which differed by their own brand of products used ad libitum: (a) cigarette and e-cigarette (dual), (b) cigarette-only, (c) e-cigarette-only, and (d) no tobacco/nicotine. Primary outcomes included daily tobacco use, expired air carbon monoxide (CO), and urinary cotinine and NNAL. Linear mixed models with pairwise comparisons (Bonferroni corrected) were performed (p < .05). CPD did not differ significantly between dual and cigarette-only use, but e-cigarette use and liquid consumed increased significantly during e-cigarette-only relative to dual use. Relative to dual use, expired air CO did not differ during cigarette-only and was significantly lower during e-cigarette-only use. Urinary cotinine was significantly lower during e-cigarette-only use relative to dual and cigarette-only use, while urinary NNAL did not differ between the nicotine-containing conditions. In summary, among current dual users, e-cigarettes in combination with cigarettes did not reduce CPD relative to exclusive cigarette use or toxicant exposure relative to exclusive use of either product. However, exclusive e-cigarette use did reduce CO and cotinine, highlighting the benefits of cigarette cessation. (PsycInfo Database Record (c) 2020 APA, all rights reserved). |
Databáze: | OpenAIRE |
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