Chemical modification of coumarin dimer and HIV-1 integrase inhibitory activity

Autor:	Hervé Leh, Ling-Yih Hsu, Christian Auclair, Jean-Francois Mouscadet, Pili Chih-Min Mao
Rok vydání:	2002
Předmět:	Magnetic Resonance Spectroscopy Stereochemistry Dimer Hydrophobic moiety HIV Integrase Inhibitory postsynaptic potential Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Coumarins Drug Discovery Humans heterocyclic compounds HIV Integrase Inhibitors chemistry.chemical_classification biology Molecular Structure Chemical modification General Chemistry General Medicine Coumarin Integrase Enzyme chemistry Enzyme inhibitor Hiv 1 integrase biology.protein HIV-1 Linker Dimerization
Zdroj:	Chemicalpharmaceutical bulletin. 50(12)
ISSN:	0009-2363
Popis:	A systematic series of chemically modified coumarin dimmers has been synthesized and tested for their inhibitory activity against HIV-1 integrase. We observed that modified coumarin dimmers containing hydrophobic moiety on the linker display potent inhibitory activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12273b8c809068125ac0c22b153cfb94 https://pubmed.ncbi.nlm.nih.gov/12499608 Zobrazit plný text záznamu