Histologic Comparison of Cultured Epithelial Autograft and Meshed Expanded Split-thickness Skin Graft
| Autor: | Charles F. T. Snelling, Michael Putland, Victor Tron, Ian Macdonald |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty Time Factors medicine.medical_treatment Tissue Expansion Epithelium Basal (phylogenetics) Split thickness skin graft Culture Techniques Biopsy medicine Humans General Nursing medicine.diagnostic_test biology business.industry Graft Survival Rehabilitation Epithelial Cells Histology Skin Transplantation Anatomy medicine.anatomical_structure Homogeneous General Health Professions Emergency Medicine biology.protein Surgery Epidermis Burns business Elastin Tissue expansion |
| Zdroj: | Journal of Burn Care & Rehabilitation. 16:627-640 |
| ISSN: | 0273-8481 |
| Popis: | Histologic appearance of cultured epithelial autograft (CEA) biopsies obtained up to 2100 days after application from patients with burn injuries differs from time-matched, meshed expanded autograft. The CEA interface with underlying bed remained flat for up to 3 years in three of four patients. CEA epidermal rete ridges, if formed subsequently, were fewer, thinner, and shorter, whereas expanded split-thickness skin grafts had well-defined rete ridges after 1 year. CEA basal layer remained separated from its bed up to 50 days after application, and late blister formation was seen on occasion for up to 3 years. The underlying bed was homogeneous up to 2 years; later some beds demonstrated differentiation with superficial, fine, filamentous collagen fibers and deeper, thick collagen fibers. Fine elastin filaments were initially identified in the superficial bed after 1 year in some specimens and in all after 3 years. Delay in rete ridge formation may explain poor adherence and poor stability. |
| Databáze: | OpenAIRE |
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