A Study in Patients with Erectile Dysfunction Comparing Different Formulations of Prostaglandin E1
| Autor: | W H Weiske, F G Ogrinc, Dirk Vanderschueren, H J de Koning Gans, R M Heyrman, E J Keogh, R W Casey |
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| Rok vydání: | 1995 |
| Předmět: | |
| Zdroj: | Journal of Urology. 154:1744-1747 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(01)66774-0 |
| Popis: | Purpose: Prostaglandin E1 sterile powder and sterile solution are 2 new formulations of exogenous prostaglandin E1 that are more convenient for auto-injection therapy for erectile dysfunction than the presently used pediatric sterile solution. Therefore, the pharmacodynamic profiles of intracavernous prostaglandin E1 sterile powder and nonalcohol sterile solution were compared with the pediatric sterile solution in men with erectile dysfunction who were known to be stable responders to intracavernous prostaglandin E1.Materials and Methods: Based on the dose used at home, patients were randomized to 1 of 5 dose groups: 0 microgram (placebo), 2.5 microgram, 5 microgram, 10 microgram or 20 microgram. Each patient received a single injection of the same dose of each of the 3 formulations. The primary pharmacodynamic end points were clinical evaluation of erectile response, RigiScan† †Dacomed, Minneapolis, Minnesota. real-time evaluation of erectile response and patient evaluation of erectile response.... |
| Databáze: | OpenAIRE |
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